
TRAUMA
This year’s general theme is deeply relevant to our contemporary life: trauma and the brain under stress. From the complex mechanisms of neurobiology to effective strategies for resilience and intervention, we will explore trauma from multiple perspectives.
This conference will provide a comprehensive understanding of how trauma affects the brain, shapes behavior, and impacts mental health and society. Join us as we examine the science, prevention, and treatment of trauma, fostering dialogue and innovative approaches among experts from diverse fields.

Speakers Bio
Aline Desmedt, Ph.D

Professor of neuroscience at the University of Bordeaux and team leader at the Neurocentre Magendie
Aline Desmedt is a professor of neuroscience at the University of Bordeaux and team leader at the Neurocentre Magendie ("Physiopathology of declarative memory", INSERM U1215). Her research focuses in particular on the neurobiological bases of traumatic memory. After obtaining a doctorate in neuroscience at the University of Bordeaux, A. Desmedt completed postdoctoral training at the Weizmann Institute of Science in Israel. Laureate of 2 scientific awards, she coordinates several scientific projects dedicated to the brain bases of post-traumatic stress disorder and is the author of numerous scientific articles on this topic and more than 70 invited conferences. After having developed the first animal (mice) model of traumatic memory (Kaouane et al., Science, 2012), she recently demonstrated that a re-contextualization of traumatic memory can «normalize» this pathological memory (e.g. Al Abed et al., Nature Com, 2020).
Dr. Paola Castellano

Psychologist and Research Fellow Sapienza University
Dr. Paola Castellano is a psychologist and psychotherapist in training. She currently holds a research fellowship at the Department of Psychology, Sapienza University of Rome, where her work focuses on psychophysiological indicators of depression. She is also a scientific collaborator at the Institute of Neuroscience, Université catholique de Louvain, where she investigates the relationship between psychological factors and pain. Dr. Castellano obtained her PhD from the Alma Mater Studiorum – University of Bologna, with a dissertation investigating the individual psychological factors involved in health and illness behaviors and the psychophysiological consequences of antibiotic misuse. Her main research interests include clinical psychology, mood disorders, neuroscience, and the biopsychosocial aspects of health and pain.
Tomas Ros, Ph.D

Lecturer University of Geneva
Dr. Tomas Ros is a Senior Lecturer at the Department of Clinical Neuroscience at the University of Geneva, specializing in the methodological development of EEG neurofeedback for psychiatric and neurological conditions. His research is driven by a fascination with the link between brain function and human behaviour, a passion he pursued through his PhD in Psychology at Goldsmiths, University of London (2010).
As a postdoctoral fellow at Western University in Canada, he investigated neurofeedback as a potential treatment for post-traumatic stress disorder (PTSD), work that earned him the Brain Star Award from the Canadian Institutes of Health Research. At the University of Geneva, he has expanded these applications to pioneer new therapies for post-stroke rehabilitation and attention-deficit hyperactivity disorder (ADHD).
Dr. Ros holds a PhD from Goldsmiths College, an MSc in Neuroscience from Louis Pasteur University, and a BSc in Physics from Imperial College of Science and Technology.
Prof Richard J. Contrada

Professor at Rutgers University, Department of Psychology; Institute for Health, Healthcare Policy, and Aging Research
Prof. Richard Contrada is a health psychologist, professor in the Department of Psychology and member of the Institute for Health, Healthcare Policy, and Aging Research at Rutgers, The State University of New Jersey (U.S.A.). He has conducted biopsychosocial research on cardiovascular disorders and other medical conditions, represented in over 100 publications. Prof. Contrada’s work has been supported by the National Institutes for Health (NIH), American Heart Association, Charles A. Dana Foundation, and the Fetzer Institute. He also served as Co-Investigator and Project Director of an NIH Center on promoting health in African Americans, and Co-Director of an NIH Mind-Body Center. Prof. Contrada is a Fellow of the Society for Biopsychosocial Science and Medicine (formerly the Psychosomatic Society), Academy of Behavioral Medicine Research, and American Psychological Association, among other scientific organizations.
Michael Duffy, Ph.D.

Senior Lecturer and Director of the Specialist MSc (Trauma) in Cognitive Behavioural Therapy at Queen’s University Belfast
Dr Michael Duffy is a Consultant Cognitive Psychotherapist specialising in PTSD and complex grief and Senior Lecturer and Director of the Specialist MSc (Trauma) in Cognitive Behavioural Therapy at Queen’s University Belfast. He leads the QUB Trauma Research Network; is a Fellow of the Centre for Evidence and Social Innovation; Assoc. Fellow of the George J Mitchell Institute for Global Peace Security & Justice and Fellow of the British Association for Behavioural and Cognitive Psychotherapy. He is research advisor to the Northern Ireland Regional Trauma Network and a member of the UK Trauma Council. Michael led the work of the Trauma team after the Omagh bombing in 1998 and published several studies into the psychological effects of this event on adults, children and adolescents. He later was Team Leader at the Northern Ireland Centre for Trauma (NICTT) and led 2 clinical trials on the application of TF-CT for conflict related PTSD. He has provided many workshops on PTSD after large scale traumas including: 2004, New York the 9/11 Twin Towers attack; 2005, 7/11 London bombings; 2012 Oslo bombing and Utoya Island shootings; 2017, the Manchester Concert bomb. His main research area is on PTSD and evidence-based psychological interventions. Currently, his research relates to cognitive therapy for complex grief and he is CI on a NIHR funded multi site RCT to explore the question- “Does a phased approach enhance outcomes for CT-PTSD for Complex PTSD?”
Dylan Gee, Ph.D.

Yale University
Dr. Dylan Gee is a Professor of Psychology at Yale University, where she directs the Clinical Affective Neuroscience and Development Laboratory (CANDLab). Dr. Gee received her bachelor’s degree from Dartmouth College, her Ph.D. in Clinical Psychology from the University of California Los Angeles, and completed her clinical internship and postdoctoral fellowship at Weill Cornell Medical College. Her lab’s research focuses on neurodevelopmental mechanisms of early adversity and risk for psychopathology in childhood and adolescence, with a translational focus to inform interventions and policy related to youth well-being. In addition to her lab’s research, she serves as a co-principal investigator at the Yale site of the Adolescent Brain Cognitive Development (ABCD) Study. Dr. Gee was selected as a World Economic Forum Young Scientist and her work has received broad recognition, including the American Psychological Association’s Distinguished Scientific Award for Early Career Contributions to Psychology, the Janet Taylor Spence Award for Transformative Early Career Contributions from the Association of Psychological Science, and the American Psychological Association’s Early Career Award for Outstanding Contributions to Children, Youth, and Families. Dr. Gee frequently gives talks to parents and educators, and her lab’s work has had a notable impact on public policy related to child development and mental health.
Andrei Miu, Ph.D

Professor of Cognitive Neuroscience and Behavioral Genetics and founding Director of the Cognitive Neuroscience Laboratory
Andrei C. Miu is Professor of Cognitive Neuroscience and Behavioral Genetics and founding Director of the Cognitive Neuroscience Laboratory (http://www.cognitive-neuroscience.ro/) in the Department of Psychology at Babeș-Bolyai University, Cluj-Napoca, Romania. He holds a B.A. in Psychology, an M.Sc. in Neuroscience and Molecular Medicine, and a Ph.D. in Psychology with an interdisciplinary thesis on emotion and cognition. His research examines individual differences in emotion — including their neural and genetic underpinnings — and their impact on cognition and risk for psychopathology. Recently, his work has focused on emotion regulation as a mechanism linking childhood maltreatment to psychopathology, using behavioral, neurophysiological, neuroendocrine, and genetic methods.
Dr. Miu has authored over 80 peer-reviewed articles, several designated Highly Cited Papers (top 1% in Psychiatry/Psychology) on Web of Science. He has received fellowships and awards from Fulbright, Go8 Future Research Leaders (Australia), and SEMPRE (UK), among others
Carmen Pedraza Benitez, Ph.D

Professor of Psychobiology at the University of Malaga
Professor of Psychobiology at the University of Malaga, she specializes in Neuroscience research and teaching. She holds both a BA and PhD in Psychology from the same institution, where she earned the Extraordinary Doctoral Award. Her academic journey began with a collaboration grant, followed by several roles within the university, which have enabled her to develop a robust research focus on the role of lipid transmitters in neurogenesis and behavior. Recently, her work has expanded to exploring the intersection of stress, neuroinflammation, neuroplasticity, and, more recently, the gut microbiome, particularly in relation to depressive disorders.
Over the course of her career, she has led numerous research projects funded through competitive calls and has collaborated with national and international research teams. Her findings have been published in over 70 indexed scientific articles. Some of her work has received awards from the General Foundation of the University of Malaga, and several of her publications have been recognized for their significant contribution to understanding human diseases, with notable mentions in Global Medical Discovery and World Biomedical Frontiers. In addition to research, she teaches at undergraduate, master's, and doctoral levels and supervises doctoral theses. She also participates in academic management and knowledge transfer initiatives with industry, seeing the university as a hub for dialogue between science, education, and society.
Prof. Richelle Mychasiuk

Professor in the Department of Neuroscience, School of Medical Sciences, University of Sydney
Richelle is a Professor in the Department of Neuroscience, within the School of Medical Sciences at the University of Sydney. She has held previous appointments at Monash University within the School of Translational Medicine, and at the University of Calgary, Department of Psychology. Her research program aims to understand how early life experiences regulate susceptibility to sleep disturbances, chronic pain, and post-concussive symptomologies in adolescents. She is particularly interested in understanding the effects that perinatal trauma and adverse childhood experiences have on adolescent neurodevelopment, and how these processes differ for males and females. Within this realm, her lab is interested in understanding how early life experiences get “under the skin” to shape neurodevelopment, modulate neuroplasticity, and increase an individual’s risk for the development of chronic pain and sleep disorders. Taken together, her laboratory specialises in the translation of discovery science and preclinical animal models to human, clinical populations, through robust, mutually beneficial collaborations with clinical researchers.
Dr. Judith K. Daniels

Professor of Clinical Psychology
Judith Daniels is a PhD, is a scientist-practitioner at the University of Groningen, The Netherlands. She studied psychology at the universities of Giessen and Bielefeld (Germany) and received a PhD from the University of Bielefeld. After completing a postdoctoral fellowship at Western University in London, Canada, she headed a research group at Charite Berlin, Germany. She then became assistant professor at the Department of Psychosomatics at the University of Magdeburg, Germany. Since 2015, she has been a professor at the Faculty of Behavioral and Social Sciences at the University of Groningen, where she holds a chair in Clinical Psychology. She is also the head of the research department at Traumacentrum Beilen, GGZ Drenthe, The Netherlands, which is a specialized treatment facility for complex cases of Posttraumatic Stress Disorder. In the last 20 years, she has conducted research on Posttraumatic Stress Disorder and Dissociative Disorders.
Maria-Magdalena Macarenco

Ph.D.
Maria-Magdalena Macarenco is doctor in Psychology, clinical psychologist, psychotherapist, EMDR consultant, supervisor, and trainer. With over 20 years of experience in clinical practice, she specializes in trauma and psychological trauma therapy. Since 2013, she has been offering continuing education courses in psychotraumatology. Her areas of professional interest include post-traumatic stress disorder (PTSD) and complex PTSD; Dissociation and psychotraumatic mechanisms; Adverse childhood experiences (ACEs); The connection between trauma and autoimmune diseases; Trauma-oriented psychotherapy.
Prof. Dr. Inga Schalinski

Licensed psychological psychotherapist
Prof. Dr. Inga Schalinski is a researcher and licensed psychological psychotherapist with expertise in trauma-related fields. She holds a full professorship at the University of the Bundeswehr Munich (Germany). Her research focuses on childhood maltreatment and its impact on both mental and physical health, with a particular emphasis on the neurobiology and treatment of dissociative symptoms. She has published numerous research papers in leading academic journals, advancing knowledge on the long-term consequences of childhood maltreatment.
Marcelo Matias

Existential psychotherapist (MBACP Accred) and supervisor
Marcelo Matias (he/him) is an existential psychotherapist (MBACP Accred) and supervisor. With extensive experience with individuals, couples and groups, he specializes in burnout, identity, sexuality, and workplace stress. He concluded a Doctorate in Counselling Psychology and Psychotherapy, focusing his research on gay men's workplace burnout and recovery. He is Brazilian and London-based.
Marie Mennesson, Ph.D.

Preclinical researcher
Marie Mennesson completed her Bachelor's degree in Cell Biology and Physiology and her Master's degree in Neuroscience at the University of Bordeaux, France. I then pursued a PhD in Neuroscience at the University of Helsinki, Finland, under the supervision of Professor Iiris Hovatta. During my PhD, I worked on the kainate receptor auxiliary subunits NETO1 and NETO2 in anxiety- and fear-related behaviors. In this project, I showed that the NETO2 protein was necessary for normal fear expression and extinction memory, two processes often disrupted in patients suffering from post-traumatic stress disorder (PTSD). After defending my PhD, I returned to Bordeaux and joined the Dr. Jean-Michel Revest's laboratory at the Neurocentre Magendie as a postdoctoral researcher. In this project I focused on the role of PAI-1 protein (tissue plasminogen activator inhibitor-1) as a blood biomarker for the diagnosis of PTSD, but also as a new therapeutic target for treating this trauma-related illness.
Olga Kukharuk, Ph.D.

Psychologist, psychotherapist, and Psychology researcher
Dr. Olga Kukharuk is a psychologist, psychotherapist (СBT, EMDR), and researcher with a PhD in Psychology. Her professional focus lies in trauma-informed interventions, social cohesion, and the use of immersive technologies in mental health care. She leads the psychological and research development of Luminify, a VR-based psychological support program designed for trauma-affected individuals, service members, and veterans in Ukraine. Dr. Kukharuk also collaborates with international research and professional networks on projects integrating neuroscience, virtual reality, and evidence-based psychotherapeutic frameworks to enhance resilience and recovery.
Dr. Karla L. Sapp

Licensed psychotherapist, clinical supervisor
Dr. Karla L. Sapp, LPC-S, LMHC-S, LCMHC-S, RYT-500, is a licensed psychotherapist, clinical supervisor, and registered yoga teacher with over 15 years of experience working at the intersection of mental health, trauma recovery, and criminal justice reform. Her clinical expertise centers on the treatment of developmental trauma, adverse childhood experiences (ACEs), and their long-term impact on neurodevelopment, emotional regulation, and behavioral health.
Dr. Sapp has served diverse populations, including justice-involved individuals, survivors of complex trauma, and at-risk youth, blending evidence-based psychotherapeutic approaches with mindfulness, breathwork, and somatic practices to promote resilience and healing. Her work integrates neuroscience, psychology, and criminology to create trauma-informed frameworks that disrupt cycles of harm and reduce recidivism.
An advocate for systemic change, Dr. Sapp has provided training and consultation for mental health professionals, educators, and justice system stakeholders on implementing neurodevelopmentally informed interventions. Her research and presentations emphasize the ethical and practical applications of neuroscience in policy reform and rehabilitation programs.
In addition to her clinical and consulting work, Dr. Sapp is an active contributor to professional publications and conference proceedings, focusing on the intersection of trauma, neurobiology, and justice. She brings both academic rigor and compassionate insight to her work, fostering dialogue that bridges science and practice.
Ioana Iuga

Clinical psychologist and cognitive-behavioral psychotherapist
Ioana Iuga is a clinical psychologist and cognitive-behavioral psychotherapist, certified by the Romanian Board of Psychologists. She has recently defended her doctoral thesis at the Doctoral School of Evidence-Based Assessment and Psychological Interventions, Babeș-Bolyai University, Cluj-Napoca on the topic of emotion regulation, attachment and student burnout. Her work focuses on emotion regulation, school burnout, and the development of evidence-based interventions for adolescents. Ioana has been actively involved in designing, implementing, and evaluating intervention programs that bring scientific findings into practice, with the aim of improving youth mental health and resilience.
Simona Miron

Clinical Psychologist at the PsyTech University Clinic
Simona Miron is currently a clinical psychologist at the PsyTech University Clinic and a doctoral student at the Doctoral School of Evidence-Based Assessment and Psychological Interventions at Babeș-Bolyai University in Cluj-Napoca. She completed her undergraduate program with a specialization in Forensic Psychology at Tilburg University and her master’s degree in Clinical Psychology, Psychological Counseling, and Psychotherapy at Babeș-Bolyai University. Her main research interests focus on the development of disruptive behaviors in children and adolescents and their connection to juvenile delinquency, as well as effective therapy for individuals with personality disorders and aggressive behaviors within couple relationships.
Zoe Wyatt-Potage Ph.D.

Clinical Social Worker
Dr. Zoe Wyatt-Potage is a Clinical Social Worker (PhD) and global consultant in trauma and wellbeing. With over a decade of experience across Southeast Asia, Africa, and Australia, her work bridges neuroscience, trauma-informed care, and organisational practice. Her doctoral research focused on trauma and resilience, and she continues to publish and present internationally on vicarious trauma, burnout and the neuroscience of wellbeing.

9:00-10:00 – Dr. Maria-Magdalena Macarenco – Unseen Divisions of Self: Dissociation as a Trauma-Related Survival Mechanism
10:00-11:00 – Dr. Aline Desmedt – Contextualizing the trauma representation prevents and/or treats PTSD-like memory
11:00-13:00 – Prof. Judith K. Daniels, Dr. Mria-Magdalena Macarenco, Prof. Inga Schalinski, – Discussion Panel: Neuro- and Psychological Mechanisms of Dissociation as a Coping Strategy for Trauma
13:00-14:00 – break
14:00-15:00 – Paola Castellano – The Influence of Depressive Traits and Pain on Health-Related Neural Processing
15:00-16:00 – Dr. Dylan G. Gee – How early-life stress affects brain development and mental health
16:15-17:15 – Prof. Richard J. Contrada – Transdiagnostic cognitive-affective and physiological mechanisms involved in anxiety, stress, and trauma
17:30-18:30 – Dr. Carmen Pedraza Benitez – Unravelling stress-induced depression: Neuroinflammation, neuroplasticity and the role of sex and individual differences
program day 1
9:00-10:00 – Dr. Marcelo Matias – Minority Stress and Burnout Recovery
10:00-11:00 – Prof. Andrei Miu – From childhood adversity to psychopathology: The role of emotion reactivity and regulation
11:00-12:00 – Dr. Marie Mennesson – Stress-induced plasminogen activator inhibitor-1 (PAI-1) as a blood biomarker and a brain risk factor for PTSD
12:00-13:00 – Prof. Richelle Mychasiuk – Harnessing Neuroplasticity to Disrupt the Intergenerational Transmission of Trauma and Foster Resiliency in Offspring
13:00-14:00 – break
14:00-15:00 – Dr. Tomas Ros – Restoring alpha brain rhythms in post-traumatic stress disorder with EEG neurofeedback
15:00-16:00 – Simona Miron – Mental Health in the Digital Age: Using the REThink Life Game to Lower Emotional Distress Symptoms in Young People
16:00-17:00 – Dr. Olga Kukharuk - Bringing Virtual Reality to Psychological Support: Developing and Scaling Trauma-Informed VR Interventions in Ukraine
program day 2
11:00-12:00 – Dr. Zoe Wyatt – Scroll, Stress, Repeat: The Neuroscience of Trauma in a Digital World
12:00-13:00 – Dr. Karla L. Sapp – Early Pain, Lifelong Patterns: Developmental Trauma’s Role in the Criminal Pathway
13:00-14:00 – break
14:00-15:00 – Ioana Iuga – Understanding and Preventing School Burnout in Students
15:00-16:00 – Dr. Michael Duffy - Lessons from psycho-trauma research and treatment of PTSD linked to the recent conflict in Northern Ireland
16:00-18:00 – Dr. Deborah Bryon, Petar Daneski, Dr. Sue Grand – Discussion Panel: Carrying the Weight of Trauma
program day 3
Day 1
The neurobiology of trauma: understanding the mechanisms of trauma and stress and how it affects the brain.
Prof Richard J. Contrada
Professor at Rutgers University, Department of Psychology; Institute for Health, Healthcare Policy, and Aging Research

Cognitive-Affective traits, Psychopathology, and Cardiovascular Disease: The Role of Stress-Related Mechanisms
Personality attributes involving negative affect, as well as mental disorders including depression, anxiety, and posttraumatic stress disorder, are cardiovascular risk factors. However, their independent contributions to disease, and the implications of their overlap, combinations, and interactions, are poorly understood. Potential explanatory mechanisms are the subject of a large and growing body of research, much of which focuses psychobiological processes initiated by stress. Mechanism-focused research implicates these traits and conditions as causal determinants of cardiovascular disease. But findings of intervention trials are uncertain regarding the effectiveness of psychological treatments for modifying them to reduce their impact on cardiovascular disease. Promising recent developments include novel perspectives on mental disorders; examination of the interplay between cognitive and emotional processes; and theoretical frameworks that integrate psychological stress processes with neuroscience, health behavior, and social cognition. Regarding neuroscience, one promising direction for integrating future mechanistic and intervention research is greater use of electrocortical markers such as event-related potentials.
Maria-Magdalena Macarenco
Ph.D.

Unseen Divisions of Self: Dissociation as a Trauma-Related Survival Mechanism
Dissociation is a fundamental survival response to trauma, encompassing both direct forms (such as depersonalization, derealization, and amnesia) and more subtle, indirect expressions that fragment cognition, affect, and bodily awareness. While protective in overwhelming situations, chronic dissociation can become maladaptive, shaping vulnerability across mental and physical health.
This presentation will highlight dissociation as a central pathway linking trauma to long-term outcomes. Drawing on recent empirical work, I will present findings suggesting that dissociation mediates the relationship between childhood trauma and autoimmune disease, suggesting that survival mechanisms rooted in the psyche can reverberate into the body. Additionally, findings from two randomized controlled trials will be discussed, showing that targeted trauma therapies — Identity-Oriented Psychotrauma Therapy (IOPT) and Eye Movement Desensitization and Reprocessing (EMDR) — significantly reduced dissociation in patients with Hashimoto’s thyroiditis.
By addressing dissociation in both its visible and less apparent forms, this talk reframes it not only as a symptom but as a key bridge between trauma, mind, and body. Understanding and treating dissociation thus holds potential for advancing integrative approaches to healing.
Dylan Gee, Ph.D.
Yale University

The Developing Brain Under Stress
Early-life stress is a potent risk factor for psychopathology, yet individuals exposed to adversity show substantial variability in development and mental health outcomes. Delineating neurobiological mechanisms related to risk and resilience is critical for identifying youth who could most benefit from early intervention and for tailoring effective treatments. My research program leverages a multimodal approach to investigate how early experiences shape brain and behavioral development, with a particular focus on corticolimbic circuitry involved in emotional learning and regulation. This talk will explore how early-life stress influences the development of this circuitry in nuanced ways that can promote adaptive functioning in stressful environments but also confer risk for mental health disorders. I will also highlight novel approaches for parsing heterogeneity in the effects of stress and discuss how insights from developmental neuroscience can enhance efforts to optimize treatments for stress-related disorders in youth.
Aline Desmedt, Ph.D
Professor of neuroscience at the University of Bordeaux and team leader at the Neurocentre Magendie

Contextualizing the trauma representation prevents and/or treats PTSD-like memory
Post-traumatic stress disorder (PTSD) is characterized by a paradoxical memory alteration with hypermnesia for salient traumatic cues and amnesia for the traumatic context. Clinical studies strongly suggest that a deficit in trauma contextualization would leave traumatic memory out of control and thus prone to be automatically reactivated upon trauma-related cues in any context through flashbacks. In this view, recovery from PTSD-related hypermnesia would thus depend on recovery from contextual amnesia. Yet, preclinical research focuses exclusively on traumatic hypermnesia, leaving unexplored the putative causal role of a deficit in the hippocampus-dependent trauma contextualization in PTSD.
Using the first animal (mice) model that precisely recapitulates the two memory components of PTSD (e.g. traumatic hypermnesia & contextual amnesia), we first show that compared to normative (contextual) fear memory, PTSD-like fear memory is specifically associated with hippocampal hypoactivation and neuronal alterations. Second, we show that optogenetic inhibition of the hippocampus (dCA1) during stress can produce PTSD-like memory, whereas activating the dCA1 in a traumatic condition prevents its formation and promotes normative contextual fear memory. Finally, trauma re-contextualization by evocation of the traumatic memory in the original traumatic environment normalizes PTSD-like memory, promoting the expression of a long-lasting normative fear memory.
These findings indicate that PTSD-like memory depends on contextual amnesia and that promoting the hippocampal function promotes a switch from PTSD-like to normal fear memory via trauma contextualization. Therefore, these data call for promoting therapeutic approaches of PTSD centered on trauma contextualization and its underlying hippocampal mechanisms.
Carmen Pedraza Benitez, Ph.D
Professor of Psychobiology at the University of Malaga

Unravelling stress-induced depression: Neuroinflammation, neuroplasticity and the role of sex and individual differences
Stress is a major risk factor for the development of depression, yet its impact is highly variable across individuals. Emerging evidence highlights neuroinflammation and impaired neuroplasticity as key mechanisms mediating stress-induced depressive phenotypes. Chronic stress promotes activation of microglia, release of pro-inflammatory cytokines, and disruption of synaptic connectivity, leading to altered structural and functional plasticity in stress-sensitive brain regions such as the hippocampus, prefrontal cortex, and amygdala. However, the extent of these changes is strongly shaped by biological sex and individual differences, including genetic predispositions, hormonal status, and prior life experiences.
This presentation will examine how neuroinflammation and maladaptive plasticity interact with sex- and individual-specific factors to determine susceptibility or resilience to stress-induced depression. Understanding these mechanisms is essential to refine personalized therapeutic strategies, paving the way to understand stress and the brain.
Dr. Paola Castellano
Ph.D

The Influence of Depressive Traits and Pain on Health-Related Neural Processing
External stimuli are constantly processed by the human brain, and health-related cues can elicit distinct neural responses depending on individual psychophysiological characteristics. This study investigated how individual psychophysiological traits influence the neural processing of health-related stimuli in healthy participants. Brain activity was recorded using electroencephalography (EEG) during a Fast Periodic Visual Stimulation (FPVS) paradigm, in which health-related images were presented periodically among neutral stimuli. A sample of 41 participants (mean age = 25.17 ± 6.3; 32 females) completed questionnaires assessing depressive traits, anxiety, perceived stress, emotional regulation, and coping strategies, and underwent measurement of thermal pain thresholds.
Results indicated that stronger neural responses to health-related stimuli were associated with higher depression scores. Moreover, emotional regulation predicted individual differences in pain threshold, which in turn moderated the relationship between depressive symptoms and neural responses. These findings suggest that individual differences in affective characteristics and pain sensitivity influence how salient health-related information is processed at the neural level.
This study extends the application of the FPVS paradigm to abstract, health-related content and emphasizes the importance of integrating psychological, physiological, and neural measures to better understand inter-individual variability in non-clinical populations.
Panel Day 1
Neuro and Psychological Mechanisms of Dissociation as a Coping Response to Trauma
This panel will focus on dissociation as a psychological and neurobiological response that can occur in the face of overwhelming or traumatic experiences.
Understanding dissociation is crucial for improving clinical approaches and support systems. In this panel, we aim to unpack the underlying neural circuits, psychological theories, and adaptive or maladaptive functions of dissociation as a coping mechanism.

Prof. Inga Schalinski
Licensed psychological psychotherapist, and Professor for Clinical Psychology and Trauma therapy at the University of the Bundeswehr, Munich

Prof. Judith K. Daniels
Head of the research department at GGZ Drenthe, and Professor in the Faculty of Behavioral and Social Sciences at the University of Groningen
Day 2
Models and Interventions for trauma recovery: discussing traditional, emerging, and holistic interventions that promote healing and resilience.
Simona Miron
Clinical Psychologist at the PsyTech University Clinic

Mental Health in the Digital Age: Using the REThink Life Game to Lower Emotional Distress Symptoms in Young People
Digital mental health interventions are growing popular due to an increased demand for accessible, ecologically valid means to deliver a quick and reliable relief to distress. The REThink Life Game is a great example of evidence-based digital therapeutic tools, targeting a range of emotion regulation skills rooted in Rational Emotive Behavioral Therapy (REBT), such as mindfulness and frustration tolerance. It has been used as a standalone intervention in a sequential multiple assignment randomized trial involving highly distressed college students and has shown promising results in decreasing negative emotions, as well as symptoms of depression and stress, with medium to large effect sizes. The REThink Life Game can be used in the 3D version or with a VR headset and has several customizable features, allowing researchers to deliver the four core levels with or without a coaching component. There is also an integrated assessment system to evaluate players’ emotional abilities, for which young adults have assigned good usability scores on all domains, such as relevance to personal interests and adequacy of the learning material, proving that delivering digital mental health tools in this population should be encouraged.
Tomas Ros, Ph.D
Lecturer University of Geneva

Restoring alpha brain rhythms in post-traumatic stress disorder with EEG neurofeedback
Posttraumatic stress disorder (PTSD) is consistently associated with a key electroencephalogram (EEG) signature: pathologically reduced alpha (8-12 Hz) rhythms. Our objective was to provide mechanistic evidence that a targeted neurofeedback (NFB) protocol could normalize this aberrant brain activity and thereby produce clinical improvement. In a 20-week, double-blind, randomized controlled trial, we assigned 38 patients with PTSD to either an experimental group (n=20) receiving alpha-desynchronizing NFB or a sham-control group (n=18). We assessed resting-state EEG and clinical severity at baseline, post-treatment, and a 3-month follow-up. At baseline, we first confirmed that patients with PTSD exhibited significantly lower alpha power than healthy controls (n=32), primarily within the anterior default mode network (DMN). Following the intervention, we found that only the experimental NFB group demonstrated significant alpha resynchronization in these deficient DMN regions. This neural normalization was paralleled by a significant decrease in PTSD severity scores at post-treatment (Cohen’s d = 0.77) and at the 3-month follow-up (Cohen’s d = 0.75), culminating in a 60.0% remission rate. Our results indicate that this neurofeedback protocol triggers a homeostatic "alpha rebound effect," rescuing a functional biomarker linked to hyperarousal. This trial provides long-term evidence linking the normalization of DMN alpha rhythmicity to lasting symptom remission in PTSD.
Andrei Miu, Ph.D
Professor of Cognitive Neuroscience and Behavioral Genetics and founding Director of the Cognitive Neuroscience Laboratory

From childhood adversity to psychopathology: The role of emotion reactivity and regulation
Childhood adversity — negative events that overwhelm children’s coping resources and produce prolonged stress (e.g., maltreatment, violence exposure, serious illness, disasters) — is linked to elevated risk for nearly all common mental disorders. Yet the psychological pathways remain incompletely understood, limiting precision prevention and treatment. Our work examines two candidate mechanisms: emotion reactivity and emotion regulation. I will present converging evidence from laboratory and field studies, and from a quantitative synthesis, showing that adversity is associated with reduced expressive flexibility in the lab (the ability to up- or down-shift emotional display to fit context), with less frequent use of reappraisal and savoring, lower positive affect, higher negative affect, and reduced momentary regulation success in daily life (experience-sampling), and with broad, strategy-level regulation differences that mediate the adversity–psychopathology link in meta-analytic models. Together, these results implicate emotion reactivity and emotion regulation — especially flexibility and spontaneous strategy deployment — as modifiable targets for the next generation of preventive and therapeutic interventions.
Marcelo Matias
Existential psychotherapist (MBACP Accred) and supervisor.

Minority Stress and Burnout Recovery This presentation draws on findings from my doctoral research exploring how burnout, as a form of chronic stress, is experienced and recovered from by gay men in the UK. Using Minority Stress Theory and Critical Narrative Analysis, it highlights how stigma, identity concealment, and heteronormative work environments contribute to a uniquely embodied experience of burnout. The session reframes recovery as a narrative and relational process and offers trauma-informed, queer-affirmative insights for therapeutic and organisational contexts.
Marie Mennesson
PhD in neuroscience / Preclinical researcher

Stress-induced Plasminogen Activator Inhibitor-1 (PAI-1) as a blood biomarker and brain risk factor for PTSD
Post-traumatic stress disorder (PTSD) is a psychiatric disorder caused by experiencing a life-threatening event such as combat, natural disaster, accident and violent assault. Prevalence suggests that around 8% of people will experience PTSD in their lifetime. This disorder is characterized by an alteration of memory processes, in particular by a persistent memory of the frightening event through flashbacks or nightmares. After several months, these symptoms have a strong negative impact on daily life and well-being and can lead to severe chronic conditions such as major depression, substance abuse and/or suicide. Although this pathology is clinically well described, there is no specific biomarker available. In this translational project, focusing on the potential of a stress-reactive protein named plasminogen activator inhibitor-1 (PAI-1) as a blood biomarker and brain risk factor for PTSD, we used mice to study the importance of PAI-1 in the development of PTSD-like memory profile and then validated our preclinical findings on a longitudinal cohort of soldiers at risk of PTSD. A comprehensive behavioral analysis of full PAI-1 knock-out mice (PAI-1-/-) revealed that while PAI-1 is fully ablated, they still display a reactivity to stress (i.e., increased plasma corticosterone). Also, the ablation of PAI-1 does not affect behavior under physiological conditions, however, PAI-1-/- mice are protected from the development of a stress-induced paradoxical memory profile that resembles PSTD symptoms in humans. Additionally, we found higher levels of plasmatic PAI-1 in mice with PTSD-like memory which correlates with the severity of their profile. Interestingly, central PAI-1 expression was selectively increased in the dorsal hippocampus, a key brain structure for memory processes. Finally, we found that PAI-1 level increases in soldiers with PTSD symptoms over a one-year period whereas it was decreasing in soldiers showing low level of PTSD symptoms. Furthermore, this evolution of PAI-1 correlates positively with several psychopathology outcomes, including perceived-stress, anxiety, depression and suicidal thoughts. To conclude, PAI-1 ablation protects from developing PTSD-like memory profile and its blood and dorsal hippocampus levels are increased in this model. Also, PAI-1 blood level increases over time in soldiers with PTSD symptoms suggesting a strong potential of PAI-1 as a blood biomarker and brain risk factor for PTSD in human which could open new avenues for the diagnosis but also the treatment of this trauma-related illness.
Richelle Mychasiuk
Professor in the Department of Neuroscience, within the School of Medical Sciences at the University of Sydney

Harnessing Neuroplasticity to Disrupt the Intergenerational Transmission of Trauma and Foster Resiliency in Offspring
Post-traumatic stress (PTS) is a debilitating mental health condition that is highly prevalent in Veteran populations owing to their increased exposure to combat-related trauma. PTS is associated with numerous comorbid conditions including major depressive disorder, anxiety, and chronic pain. Although the causal mechanisms are currently unknown, both PTS and chronic pain in parents have been linked to an increased risk for pathology in their offspring. In this talk, I will discuss findings from our preclinical model of combat trauma-induced PTS where we examined the relationship between paternal PTS and offspring socio-emotional functioning, pain perception, and gene expression changes pertinent to HPA-axis functioning, reward processing, and epigenetic regulation. We have been able to demonstrate that a father’s experiences prior to conception can change offspring behaviour and gene expression, whereby offspring born to fathers who experienced combat-trauma exhibited changes to pain perception, as well as changes to social and anxiety-related behaviours. The changes in behaviour were linked to modifications in expression of numerous genes throughout the brain. These results suggest that combat-induced PTS in fathers may increase the risk for the development of chronic pain, PTS, and mental health conditions in their offspring through epigenetic processes.
Dr. Olga Kukharuk
Psychologist, psychotherapist (СBT, EMDR), and researcher with a PhD in Psychology.

Bringing Virtual Reality to Psychological Support: Developing and Scaling Trauma-Informed VR Interventions in Ukraine
The demand for psychological support in Ukraine far exceeds the available workforce, highlighting the need for scalable technologies that enhance access and efficiency. In addition to staff shortages, the absence of a coherent service delivery system, fragmented intervention formats, and post-traumatic avoidance further complicate psychological care.
To address these challenges, a team of psychologists developed and implemented both the psychological and product components of Luminify for the company Aspichi, a virtual reality (VR)–based psychological support program. Grounded in a trauma-informed and transdiagnostic approach, it targets eight core symptoms common across prevalent disorders and integrates evidence-based frameworks including CBT, Mindfulness, and ACT. The program also draws on neuropsychological mechanisms of VR influence, using immersive and multisensory engagement to enhance attention, emotional regulation, and cognitive recovery.
Program structure. Luminify includes mindfulness and recovery practices, behavioral activation, breathing and attention-training exercises, and core stabilization techniques, delivered via real 360° video and/or 3D environments. Sessions last 5–7 minutes and can be flexibly integrated into therapy or used independently.
By 2025, Luminify operates across 30+ facilities and 10 military brigades, with over 1,000 sessions monthly. Preliminary results show improved stabilization, faster therapeutic contact, and significant reductions in anxiety and depressive symptoms among veterans.
Day 3
Trauma in Society: exploring the societal, cultural, and workplace contexts in which trauma occurs and its broader, hidden impacts.
Dr Michael Duffy
Consultant Cognitive Psychotherapist specialising in PTSD and complex grief and Senior Lecturer and Director of the Specialist MSc (Trauma) in Cognitive Behavioural Therapy at Queen’s University Belfast.

Lessons from psycho-trauma research and treatment of PTSD linked to the recent conflict in Northern Ireland
The aftermath of the recent prolonged conflict in Northern Ireland has left a legacy of trauma-related illness. The first question to be considered in this presentation is how psychological factors add to our understanding of predictors of PTSD among individuals exposed to potentially traumatic events. Previous meta-analyses by Brewin et al (2000) and by Ozler et al (2003) have identified a range of predictors of PTSD but the amount of variability in PTSD that they explain is modest. I will present findings from school and community studies that investigate whether specific cognitive factors may be helpful in predicting chronic PTSD following terrorist related traumas.
In the UK, NICE guidelines recommend trauma-focused CBT (TFCBT) for the treatment of PTSD so the second question to be addressed is whether TFCBT is effective for those who experience PTSD linked to trauma and conflict.
I will present findings from our clinical studies of individuals with conflict related PTSD who were offered TFCBT based on the Ehlers & Clark (2000) model. In the first study following a single terrorist bombing in Omagh substantial and significant improvements in PTSD were observed, with pre to post treatment effect sizes (approx 2.2) in line with those reported for TFCBT in trials with non-terrorism related PTSD. In the second study patients were randomized to either immediate TFCBT or Wait list. Patients typically had chronic PTSD (range 3 months to 32 years) mostly resulting from multiple traumas. I will explain how these studies have informed our current research into complex PTSD and prolonged grief disorder.
Ioana Iuga, Ph.D.
Clinical psychologist and cognitive-behavioral psychotherapist

Understanding and Preventing School Burnout in Students. This presentation will explore the concept of school burnout among youth, highlighting its main symptoms, risk factors, and consequences for emotional and academic functioning. We will also discuss evidence-based strategies for prevention and intervention, focusing on practical tools that can be implemented by educators, parents, and mental health professionals to promote student well-being and resilience.
Dr. Zoe Wyatt-Potage
Clinical Social Worker (PhD)

Scroll, Stress, Repeat: The Neuroscience of Trauma in a Digital World. In an increasingly digitised world, our stress responses are not only shaped by real-life experiences, but also by the algorithms curating what we see, feel, and fear. This presentation explores how digital platforms - particularly their recommendation engines - may influence trauma reactivity and emotional regulation by modulating attention, perceived threat, and exposure to distressing content. Drawing from current neuroscience research, we will examine how these interactions may impact the default mode network (DMN), anterior cingulate cortex (ACC), and predictive coding mechanisms, all of which play central roles in trauma processing.
Digital ecosystems have become modern social environments - spaces where collective emotional climates are formed, amplified, and often dysregulated. From compassion fatigue to desensitisation, our neural responses to trauma are increasingly shaped by the frequency, format, and framing of what we consume online. By highlighting the neurobiological cost of constant connectivity and curated exposure, this presentation invites participants to consider how trauma-informed digital spaces might support - not undermine - neural resilience.
Dr. Karla L. Sapp
Licensed psychotherapist, clinical supervisor

Early Pain, Lifelong Patterns: Developmental Trauma’s Role in the Criminal Pathway
Abstract:
By bridging neuroscience and justice reform, this presentation offers a multidisciplinary approach to one of the most urgent challenges in mental health and criminal justice. Developmental trauma has profound and lasting effects on brain architecture, emotional regulation, and behavioral patterns, often setting the stage for cycles of criminal behavior. Adverse childhood experiences (ACEs) disrupt healthy neurodevelopment, impair stress-response systems, and influence impulse control, social functioning, and decision-making. These disruptions can lead to survival-oriented coping strategies that, over time, manifest as behaviors placing individuals at higher risk for justice system involvement.
This presentation integrates research from neuroscience, developmental psychology, and criminology to illustrate the complex interplay between early adversity and criminal trajectories. Participants will explore neurobiological mechanisms underlying trauma’s impact, examine case examples linking developmental trauma to justice involvement, and review evidence-based strategies for prevention, intervention, and rehabilitation.
Emphasis will be placed on trauma-informed frameworks capable of disrupting intergenerational cycles of harm. Attendees will leave with practical tools for applying neurodevelopmental insights in clinical, correctional, educational, and policy settings.
Panel Day 3
Carrying the Weight of Past Trauma
This panel will explore how the body and the brain carry traumatic experiences and memories over long periods of time. We will discuss a wide variety of questions, such as how unresolved trauma can manifest mentally and physically, how social and environmental factors can come into play, or what are the most compassionate but effective strategies for helping patients.

Petar Daneski
School psychologist at American High School Skopje, and Master of Arts student in Health and Counselling Psychology

Dr. Sue Grant
Licensed psychologist in New York and New Jersey, and Faculty at the New York University Postdoctoral Program in Psychoanalysis

Dr. Deborah Byron
licensed psychologist and Jungian analyst in private practice a member of International Association of Jungian Analysts (IAAP) and Inter-Regional Society of Jungian Analysts (IRSJA).
Scientific committee
Neurocon 25 Scientific Coordinators: Luana Aldea - Sapienza University, Elena Nicollin - Université de Bordeaux / IMN Bordeaux
Team: Onur Alti - Université Catholique de Louvain, Maria-Alexandra Crăciun - Babeş Bolyai University, Teresa Emma Cutrona - Sapienza University of Rome, Mădălina Daniela Dan - Psychotherapist, Alexandra Anca Danciu - Babeș-Bolyai University, Izabela Andreea Geanta - University of Bucharest, Andreea-Laura Lăpădat - Babeș-Bolyai University, Pablo Moncada Soria - University of Málaga, Abril Montes de Oca - Clinical psychologist, Diana Nakhoul - Pharmacist, Sofía Pavón Negrelos - King’s College London, Marcela Pereira - Neuroscientist, Virginia Spagnuolo - Foundation Saint Lucia, CERC, IRCCS, Clarence Faustine Tanoto - Taipei Medical University, Teodor Todorovski - Psychotherapist (Amigdala)










